Three-dimensional polymeric scaffolds may be fabricated with variable architecture depending on the organ on which they are to be transferred. Furthermore, it is also possible to produce scaffolds functionalised with bioactive molecules able to support processes of stem cell adhesion, proliferation and differentiation. The electrospinning instrumentation available at the laboratory also makes it possible to produce composite scaffolds that feature heterogeneity in terms of (a) fibre size, (b) chemical composition (c) inclusion of micro- and/or nano-particles.
Potential applications concern the use of scaffolds for in vitro cell growth and differentiation, whose architectural, chemical and bio-resorbability features may be controlled and adapted in view if the specific required application. The technology transfer may focus on the biomedical and regenerative medicine sectors, active in the production and use of polymer supports to be used as guide to cellular growth in culture.
New mimetic and nano-structured material, to be used for skin tissue repair.
One of the applications of the material concerns tissue engineering techniques and specifically skin repair treatments for in vivo regeneration of the epithelial tissue. The material, consisting of bio-compatible and bioabsorbable polymers, is produced through the electrospinning technique, which yield high porosity nanofibrous structures, biomimetic of the extracellular matrix, and which promote skin regeneration. Furthermore, the material may be applied for administering and conveying therapeutic medications with antibacterial and healing action. Products have been developed for potential applications in tissue engineering, consisting of polylactic acid nanofibres, able to support the adhesion and proliferation of various types of cells. In particular, a new biomimetic and nano-structured material has been developed, to be employed for cutaneous tissue repair. The results have been covered by a number of publications on international peer reviewed journals.
Participation in a regional project in collaboration with Ri.Mos s.r.l. entitled “New biomimetic nano-structured material from electrospinning for cutaneous tissue repair and other advanced medication uses“ Patent - Proprietor Ri.mos srl; "Substrate of polymeric material and method of carrying out thereof" PCT Patent Application (filed on November 3, 2009) at No. PCT/SM2009/000009